HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
3-Amino-6-bromopyrazine-2-carboxylic acid → Tert-butyl 1-(2-(3-amino-6-bromopyrazine-2-carboxamido)-4-methoxyphenyl)piperidin-4-ylcarbamate
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 3-Amino-6-bromopyrazine-2-carboxylic acid | HCID 18521600 | — |
| Edukt | HCID 69043362 | HCID 69043362 | — |
| Lösungsmittel | Acetonitrile | HCID 6342 | — |
| Produkt | Tert-butyl 1-(2-(3-amino-6-bromopyrazine-2-carboxamido)-4-methoxyphenyl)piperidin-4-ylcarbamate | HCID 86669183 | 7% |
Reaktionsschritte
Following method 11, tert-butyl 1-(2-amino-4-methoxyphenyl)piperidin-4-ylcarbamate was coupled to 3-amino-6-bromopyrazine-2-carboxylic acid with TEA (3 eq) in ACN at 55° C. for 48 hours. Concentrated, triturated in cold ACN, filtered, and dried in vacuo yielding tert-butyl 1-(2-(3-amino-6-bromopyrazine-2-carboxamido)-4-methoxyphenyl)piperidin-4-ylcarbamate (7%). LCMS (m/z): 521.1 (MH+); LC Rt=3.63 min.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US08822497B2 |
| Quelldatensatz | uspto-grants-2014_09 |
| ORD ID | ord-ad9762d1a2d848578ffc5fb59556b8ac |
| Quellennotiz | uspto-grants-2014_09 |