4-Nitrophenyl chloroformate → 4-nitrophenyl 2,3-dihydro-1H-inden-5-ylcarbamate

HRID 70158

Reaktionsgleichung

Reaktionsgleichung von HRID 70158
[NH2:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[CH2:7][CH2:6][CH2:5]2.Cl[C:12]([O:14][C:15]1[CH:20]=[CH:19][C:18]([N+:21]([O-:23])=[O:22])=[CH:17][CH:16]=1)=[O:13]>C(Cl)Cl>[CH2:7]1[C:8]2[C:4](=[CH:3][C:2]([NH:1][C:12](=[O:13])[O:14][C:15]3[CH:16]=[CH:17][C:18]([N+:21]([O-:23])=[O:22])=[CH:19][CH:20]=3)=[CH:10][CH:9]=2)[CH2:5][CH2:6]1

Komponenten

4

Edukt 2

HCID 821294-Nitrophenyl chloroformateHCID 90496Indan-5-amine

Produkt 1

HCID 152372784-nitrophenyl 2,3-dihydro-1H-inden-5-ylcarbamate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

5-Aminoindan (212 mg, 1.59 mmol) was dissolved in CH2Cl2 (10 mL), p-nitrophenyl chloroformate (417 mg, 2.07 mmol) was added, and the reaction mixture was stirred at rt overnight. The solid was removed by filtration (discarded), and the filtrate was concentrated under reduced pressure. This gave the title compound as a grey solid which was about 50% pure and was used without further purification. LC-MS: RT=9.98 min, [M+H]+=299.1.

Aufarbeitung

  1. customThe solid was removed by filtration (discarded)
  2. concentrationthe filtrate was concentrated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-9676e16e40bc47fe918cc08e4df9cd8f
Quelldatensatz
uspto-grants-2014_09
Patentnummer
US08822472B2

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