Hydrochloric Acid → (3-Chloro-2-fluorophenyl)(2-((pyridin-3-yloxy)methyl)piperazin-1-yl)methanone dihydrochloride

HRID 70189

Reaktionsgleichung

Reaktionsgleichung von HRID 70189
[ClH:1].O1CCOCC1.[Cl:8][C:9]1[C:10]([F:38])=[C:11]([CH:35]=[CH:36][CH:37]=1)[C:12]([N:14]1[CH2:19][CH2:18][N:17](C(OC(C)(C)C)=O)[CH2:16][CH:15]1[CH2:27][O:28][C:29]1[CH:30]=[N:31][CH:32]=[CH:33][CH:34]=1)=[O:13]>>[ClH:8].[ClH:1].[Cl:8][C:9]1[C:10]([F:38])=[C:11]([C:12]([N:14]2[CH2:19][CH2:18][NH:17][CH2:16][CH:15]2[CH2:27][O:28][C:29]2[CH:30]=[N:31][CH:32]=[CH:33][CH:34]=2)=[O:13])[CH:35]=[CH:36][CH:37]=1

Komponenten

4

Edukt 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 59671574Tert-butyl 4-(3-chloro-2-fluorobenzoyl)-3-((pyridin-3-yloxy)methyl)piperazine-1-carboxylate

Produkt 1

HCID 66797154(3-Chloro-2-fluorophenyl)(2-((pyridin-3-yloxy)methyl)piperazin-1-yl)methanone dihydrochlorideAusbeute 92 %

Versuchsvorschrift

4 M HCl in 1,4-dioxane (6 mL, 24 mmol) was added to tert-butyl 4-(3-chloro-2-fluorobenzoyl)-3-((pyridin-3-yloxy)methyl)piperazine-1-carboxylate (70 mg, 0.16 mmol). After stirring overnight, the reaction mixture was concentrated under reduced pressure, yielding 60.5 mg (92%) of the title compound. LC-MS: RT=3.80 min, [M+H]+=350.5.

Aufarbeitung

  1. concentrationthe reaction mixture was concentrated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-37dcec4e9ff44c66b5b5304693bd1385
Quelldatensatz
uspto-grants-2014_09
Patentnummer
US08822472B2

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