(+)-cis-2-Benzamidocyclohexanecarboxylic Acid → (1S,2R)-2-aminocyclohexane-1-carboxylic acid
Reaktionsgleichung
C([NH:9][C@@H:10]1[CH2:15][CH2:14][CH2:13][CH2:12][C@@H:11]1[C:16]([OH:18])=[O:17])(=O)C1C=CC=CC=1>Cl>[NH2:9][C@@H:10]1[CH2:15][CH2:14][CH2:13][CH2:12][C@@H:11]1[C:16]([OH:18])=[O:17]Komponenten
3
Edukt 1
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
A mixture of (+)-(1S,2R)-2-benzamidocyclohexanecarboxylic acid (4.0 g, 16.2 mmol, TCI chemical company) and 6 M hydrochloric acid (200 mL) was heated at reflux for 48 h. The reaction mixture was cooled to room temperature and extracted with diethyl ether (2×200 mL). The aqueous portion was concentrated in vacuo to afford (1S,2R)-2-aminocyclohexanecarboxylic acid as a white solid. The crude product was used in the next step without purification or characterization.
Aufarbeitung
- temperaturewas heated
- temperatureat reflux for 48 h
- extractionextracted with diethyl ether (2×200 mL)
- concentrationThe aqueous portion was concentrated in vacuo
Quellen und Nachweise
- ORD-Eintrag
- ord-7b337e6af2f0449cad27ae97895f7ad8
- Quelldatensatz
- uspto-grants-2006_08
- Patentnummer
- US07084178B2
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