HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
(3-Carbamoylphenyl)boronic acid → 4'-Cyano-2'-(trifluoromethyl)-3-biphenylcarboxamide
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | (3-Carbamoylphenyl)boronic acid | HCID 2737814 | — |
| Edukt | 4-Iodo-3-(trifluoromethyl)benzonitrile | HCID 22625194 | — |
| Katalysator | HCID 178418397 | HCID 178418397 | — |
| Lösungsmittel | Toluene ethanol | HCID 21863594 | — |
| Produkt | 4'-Cyano-2'-(trifluoromethyl)-3-biphenylcarboxamide | HCID 67160792 | — |
Reaktionsschritte
The title compound was synthesized from 3-(aminocarbonyl)phenyl boronic acid and 4-iodo-3-(trifluoromethyl)benzonitrile (I-IX-6) according to the procedure described for Ex IX-10, using Pd(PPh3)4 catalyst and PhMe/EtOH (4:1) as organic cosolvents. LC/MS (method A) 2.18 min, m/z 291 (M+H).
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US08822518B2 |
| Quelldatensatz | uspto-grants-2014_09 |
| ORD ID | ord-7642abc52f4148488e8c55089de794d1 |
| Quellennotiz | uspto-grants-2014_09 |