2-Fluoro-4-nitroanisole → 3-Fluoro-4-methoxyaniline
Reaktionsgleichung
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([O:10][CH3:11])=[C:6]([F:12])[CH:5]=1)([O-])=O>O1CCOCC1.[C].[Pd]>[NH2:1][C:4]1[CH:9]=[CH:8][C:7]([O:10][CH3:11])=[C:6]([F:12])[CH:5]=1Komponenten
4
Edukt 1
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 2
Versuchsvorschrift
[I] 2 g of 5% palladium carbon was added to a solution prepared by dissolving 10 g of 4-nitro-2-fluoroanisol in 150 ml of 1,4-dioxane, and the mixture was subjected to catalytic reduction under a hydrogen gas pressure of 4 kg/cm2 at room temperature for 30 minutes. After the completion of the reaction, palladium carbon was removed by filtration, and the solvent was distilled off under reduced pressure to obtain 8.6 g of 4-amino-2-fluoroanisol.
Aufarbeitung
- customprepared
- customat room temperature
- customfor 30 minutes
- customwas removed by filtration
- distillationthe solvent was distilled off under reduced pressure
Quellen und Nachweise
- ORD-Eintrag
- ord-75e9e91173c2460e983b1c6c1afaf4e5
- Quelldatensatz
- uspto-grants-1991_01
- Patentnummer
- US04985449
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