1,1,1-Trimethoxy-2-methylpropane → N-(1-Methoxy-2-methylpropylidene)-3-(2-methylphenyl)-1,2,4-thiadiazole-5-sulfonamide

HRID 704030

Reaktionsgleichung

Reaktionsgleichung von HRID 704030
[CH3:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[N:12]=[C:11]([S:13]([NH2:16])(=[O:15])=[O:14])[S:10][N:9]=1.[C:17](OC)(OC)([O:21][CH3:22])[CH:18]([CH3:20])[CH3:19]>CCCCCC>[CH3:22][O:21][C:17](=[N:16][S:13]([C:11]1[S:10][N:9]=[C:8]([C:3]2[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=2[CH3:1])[N:12]=1)(=[O:15])=[O:14])[CH:18]([CH3:20])[CH3:19]

Komponenten

4

Edukt 2

HCID 404951,1,1-Trimethoxy-2-methylpropaneHCID 141831333-(2-Methylphenyl)-1,2,4-thiadiazole-5-sulfonamide

Produkt 1

HCID 54509802N-(1-Methoxy-2-methylpropylidene)-3-(2-methylphenyl)-1,2,4-thiadiazole-5-sulfonamide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8058HexaneLösungsmittel

Versuchsvorschrift

A mixture of 3 g of 3-(2-methylphenyl)-1,2,4-thiadiazole-5-sulfonamide and 11 ml of trimethyl orthoisobutyrate was heated to reflux and stirred for 2 hours. The mixture was allowed to cool to room temperature, whereupon a precipitate formed. Hexane was added and the mixture was stirred for 15 minutes. The solid was filtered and washed with hexane and dried in vacuum (P2O5) to give 3.49 g of solid, m.p. 116°-118°.

Aufarbeitung

  1. temperaturewas heated
  2. temperatureto reflux
  3. customformed
  4. stirringthe mixture was stirred for 15 minutes
  5. filtrationThe solid was filtered
  6. washwashed with hexane
  7. dry with materialdried in vacuum (P2O5)

Quellen und Nachweise

ORD-Eintrag
ord-6455b4f259a141abbf05e8610918c59f
Quelldatensatz
uspto-grants-1991_01
Patentnummer
US04985450

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