1-Piperazinecarboxaldehyde → 4-(4-Methylpyridazino[4,5-b]indolizin-1-yl)-piperazinecarboxaldehyde

Beteiligte Stoffe

Reaktionsschritte

Following the procedure of Example 1, reaction of one equivalent of 1-chloro-4-methylpyridazino[4,5-b]indolizine and 10 equivalents of piperazinecarboxaldehyde at 150° C. gave the title compound as the free base, which was purified by flash chromatography (silica gel, 1 to 20% methanol:ethyl acetate) and converted to the dihydrochloride salt (MeOH/etheral HCl/diethyl ether), mp 325° C.

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