Keto-pantoyllactone → D-Pantolactone

HRID 704097

Reaktionsgleichung

Reaktionsgleichung von HRID 704097
[CH3:1][C:2]1([CH3:9])[C:7](=[O:8])[C:5](=[O:6])[O:4][CH2:3]1.[H][H]>C1COCC1>[CH3:1][C:2]1([CH3:9])[C@@H:7]([OH:8])[C:5](=[O:6])[O:4][CH2:3]1

Komponenten

4

Edukt 2

HCID 39Keto-pantoyllactoneHCID 178418361HCID 178418361, Verbindung

Produkt 1

HCID 439368D-Pantolactone

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Reaktionsbedingungen

Temperatur
50 °C

Versuchsvorschrift

0.0025 m-mole of rhodium-1,5-cyclooctadienechloride complex and 0.0065 m-mole of one of the asymmetric ligand compounds indicated in Table 2 were dissolved in 10 ml of THF, and 5 m-mole of ketopantolactone was added thereto. Reduction was carried out at a hydrogen atmosphere of 50 atm. The mixture was stirred at 50° C. for 45 hours. The reaction mixture was concentrated under reduced pressure and distilled under reduced pressure to obtain optically active (R)-(-)pantolactone. The results are shown in Table 2.

Aufarbeitung

  1. concentrationThe reaction mixture was concentrated under reduced pressure
  2. distillationdistilled under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-92b04c10ec5244d78ceb50444da25eac
Quelldatensatz
uspto-grants-1991_01
Patentnummer
US04985567

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