7a-nitromethyl-2,3,5,6,7,7a-hexahydro-1H-pyrrolizine → (Hexahydro-1H-pyrrolizin-7A-YL)methanamine

HRID 704102

Reaktionsgleichung

Reaktionsgleichung von HRID 704102
[N+:1]([CH2:4][C:5]12[CH2:12][CH2:11][CH2:10][N:9]1[CH2:8][CH2:7][CH2:6]2)([O-])=O>[Ni].C(O)C>[NH2:1][CH2:4][C:5]12[CH2:12][CH2:11][CH2:10][N:9]1[CH2:8][CH2:7][CH2:6]2

Komponenten

4

Edukt 1

HCID 104873597a-nitromethyl-2,3,5,6,7,7a-hexahydro-1H-pyrrolizine

Produkt 1

HCID 10654304(Hexahydro-1H-pyrrolizin-7A-YL)methanamineAusbeute 75 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 935NickelKatalysatorHCID 702EthanolLösungsmittel

Reaktionsbedingungen

Temperatur
20 °C

Versuchsvorschrift

To a suspension of Raney nickel (300 mg) in 5.0 ml of ethanol, 7a-nitromethyl-2,3,5,6,7,7a-hexahydro-1H-pyrrolizine (300 mg, 1.76 mmol, obtained in Example 1) was added and the resulting mixture was stirred for 1 hour at 20° C. under hydrogen atmosphere. The catalyst was filtered off, the filtrate was concentrated, and the resulting crude product was distilled in vacuo to afford 185 mg of the desired compound (Yield: 75%).

Aufarbeitung

  1. additionwas added
  2. filtrationThe catalyst was filtered off
  3. concentrationthe filtrate was concentrated
  4. distillationthe resulting crude product was distilled in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-78612acd1ee047b1a1d64e394c2e893f
Quelldatensatz
uspto-grants-1991_01
Patentnummer
US04985569

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