Pyridine → 1-[2-(2,3-Dihydro-3,3-dimethyl-2-oxoindol-5-yl)-2-oxoethyl]pyridinium chloride

HRID 704627Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 704627
[Cl:1][CH2:2][C:3]([C:5]1[CH:6]=[C:7]2[C:11](=[CH:12][CH:13]=1)[NH:10][C:9](=[O:14])[C:8]2([CH3:16])[CH3:15])=[O:4].[N:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1>>[Cl-:1].[CH3:15][C:8]1([CH3:16])[C:7]2[C:11](=[CH:12][CH:13]=[C:5]([C:3](=[O:4])[CH2:2][N+:17]3[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=3)[CH:6]=2)[NH:10][C:9]1=[O:14]

Komponenten

3

Edukt 2

HCID 1049PyridineHCID 107523795-(2-chloroacetyl)-3,3-dimethyl-2,3-dihydro-1H-indol-2-one

Produkt 1

HCID 200728801-[2-(2,3-Dihydro-3,3-dimethyl-2-oxoindol-5-yl)-2-oxoethyl]pyridinium chloride

Reaktionsbedingungen

Temperatur
85 °C

Versuchsvorschrift

To 5-chloroacetyl-2,3-dihydro-3,3-dimethylindol-2-one (35 g) was added pyridine (140 ml) and the mixture was stirred to 1.6 hours at 85° C. After the mixture was cooled to ambient temperature, the crystal was collected by filtration and washed with pyridine and diethyl ether successively to give 1-[2-(2,3-dihydro-3,3-dimethyl-2-oxoindol-5-yl)-2-oxoethyl]pyridinium chloride (44.6 g).

Aufarbeitung

  1. temperatureAfter the mixture was cooled to ambient temperature
  2. filtrationthe crystal was collected by filtration
  3. washwashed with pyridine and diethyl ether successively

Quellen und Nachweise

ORD-Eintrag
ord-e335379dc56f4bdd96ff1fd879934fbf
Quelldatensatz
uspto-grants-1991_01
Patentnummer
US04988698

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