Dimethylamine → N,N-dimethyl-5,6,7,8-tetrahydro-8-quinolinamine

HRID 704856

Reaktionsgleichung

Reaktionsgleichung von HRID 704856
Cl.Cl[CH:3]1[C:12]2[N:11]=[CH:10][CH:9]=[CH:8][C:7]=2[CH2:6][CH2:5][CH2:4]1.[CH3:13][NH:14][CH3:15].[Cl-].[Na+].[OH-].[Na+]>>[CH3:13][N:14]([CH3:15])[CH:3]1[C:12]2[N:11]=[CH:10][CH:9]=[CH:8][C:7]=2[CH2:6][CH2:5][CH2:4]1

Komponenten

5

Edukt 4

HCID 674DimethylamineHCID 5234Sodium ChlorideHCID 14798Sodium HydroxideHCID 137121818-Chloro-5,6,7,8-tetrahydroquinoline hydrochloride

Produkt 1

HCID 20073468N,N-dimethyl-5,6,7,8-tetrahydro-8-quinolinamine

Versuchsvorschrift

4.08 g of 8-chloro-5,6,7,8-tetrahydroquinoline hydrochloride of Example 1 were mixed with stirring for 75 minutes in 20 ml of a 40% aqueous solution of dimethylamine and the mixture was heated for 1 hour at 65° C. ±2° C., then allowed to cool to ambient temperature. The reaction medium was saturated with sodium chloride and 0.3 ml of 2N sodium hydroxide were added. After extracting with ether, the extracts were washed with water, dried, and the solvent was eliminated under reduced pressure to obtain 3.35 g of N,N-dimethyl-5,6,7,8-tetrahydro-8-quinolinamine which was used as is for the following step.

Aufarbeitung

  1. temperaturethe mixture was heated for 1 hour at 65° C. ±2° C.
  2. additionwere added
  3. extractionAfter extracting with ether
  4. washthe extracts were washed with water
  5. customdried

Quellen und Nachweise

ORD-Eintrag
ord-dd037220148844be856ca320151b5acd
Quelldatensatz
uspto-grants-1991_01
Patentnummer
US04988810

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