Benzene → Methyl 2-oxo-1,2-dihydropyridine-3-carboxylate

HRID 704858

Reaktionsgleichung

Reaktionsgleichung von HRID 704858
[O:1]=[C:2]1[C:7]([C:8]([OH:10])=[O:9])=[CH:6][CH:5]=[CH:4][NH:3]1.S(=O)(=O)(O)O.[CH:16]1C=CC=CC=1>CO>[O:1]=[C:2]1[C:7]([C:8]([O:10][CH3:16])=[O:9])=[CH:6][CH:5]=[CH:4][NH:3]1

Komponenten

5

Edukt 3

HCID 241BenzeneHCID 1118Sulfuric AcidHCID 691142-Hydroxynicotinic acid

Produkt 1

HCID 579028Methyl 2-oxo-1,2-dihydropyridine-3-carboxylate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

A mixture containing 27.8 g of 1,2-dihydro-2-oxo-3-pyridinecarboxylic acid, 3.0 ml of concentrated sulfuric acid in 500 ml of methanol, and 300 ml of benzene are heated under reflux for 2.5 hours. A Dean-Stark trap is then attached, and the azeotrope collected is removed periodically in 25 ml fractions over a period of 28 hours. The remaining solvent is removed by evaporation under reduced pressure and the solid residue suspended in 500 ml of cold water. The suspension is filtered (from which unreacted starting material can be recovered) and the filtrate continuously extracted with methylene chloride. The extracts are concentrated under reduced pressure to yield the title compound as a white solid which, upon recrystallization from 1.4 L of benzene, yields 19.48 g (64%) of methyl 2-oxo-1,2-dihydro-3-pyridinecarboxylate: m.p. 148°-151° C.; NMR (DMSO-d6, 80 MHz) delta 3.72 (s, 3H), 6.25 (dd, 1H, J=7.1 Hz, J=6.3 Hz), 7.64 (dd, 1H, J=6.3 Hz, J=2.2 Hz), 8.03 (dd, 1H, J=7.1 Hz, J=2.2 Hz).

Aufarbeitung

  1. temperatureare heated
  2. temperatureunder reflux for 2.5 hours
  3. customthe azeotrope collected
  4. customis removed periodically in 25 ml fractions over a period of 28 hours
  5. customThe remaining solvent is removed by evaporation under reduced pressure
  6. filtrationThe suspension is filtered
  7. custom(from which unreacted starting material can be recovered)
  8. extractionthe filtrate continuously extracted with methylene chloride
  9. concentrationThe extracts are concentrated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-e04471c8067f4e5d896947704291f621
Quelldatensatz
uspto-grants-1991_01
Patentnummer
US04988813

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