(5-Chloro-6-methoxypyridin-2-yl)[4-(methylsulfanyl)phenyl]methanol → HCID 58452560, Verbindung

HRID 70498

Reaktionsgleichung

Reaktionsgleichung von HRID 70498
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([CH:10]([C:12]2[CH:17]=[CH:16][C:15]([S:18][CH3:19])=[CH:14][CH:13]=2)[OH:11])=[N:6][C:7]=1[O:8][CH3:9]>C(Cl)(Cl)Cl.[O-2].[O-2].[Mn+4]>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:10]([C:12]2[CH:13]=[CH:14][C:15]([S:18][CH3:19])=[CH:16][CH:17]=2)=[O:11])=[N:6][C:7]=1[O:8][CH3:9]

Komponenten

4

Edukt 1

HCID 67396108(5-Chloro-6-methoxypyridin-2-yl)[4-(methylsulfanyl)phenyl]methanol

Produkt 1

HCID 58452560HCID 58452560, VerbindungAusbeute 72,3 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 178418406HCID 178418406, VerbindungKatalysatorHCID 6212ChloroformLösungsmittel

Reaktionsbedingungen

Temperatur
65 °C

Versuchsvorschrift

Manganese dioxide (8.34 g) was added to a solution of (5-chloro-6-methoxypyridin-2-yl)[4-(methylsulfanyl)phenyl]methanol (1.42 g) in chloroform (40 mL), and the mixture was stirred at 65° C. for one hour. The reaction solution was filtered through celite and the filtrate was concentrated. The residue was purified by silica gel column chromatography (hexane:ethyl acetate=4:1→1:1) to give the title compound as a yellow powder (1.02 g, 71%).

Aufarbeitung

  1. filtrationThe reaction solution was filtered through celite
  2. concentrationthe filtrate was concentrated
  3. customThe residue was purified by silica gel column chromatography (hexane:ethyl acetate=4:1→1:1)

Quellen und Nachweise

ORD-Eintrag
ord-05aa97b3d97643d39956e86c0a758c43
Quelldatensatz
uspto-grants-2014_09
Patentnummer
US08822503B2

Verknüpfte Notizen

Wird geladen…