3-(Cyclohexen-1-yl)aniline → N-[3-(cyclohexen-1-yl)phenyl]-4-hydroxy-3-methoxyphenylacetamide

HRID 7062

Reaktionsgleichung

Reaktionsgleichung von HRID 7062
FC1C(O[C:9](=[O:20])[CH2:10][C:11]2[CH:16]=[CH:15][C:14]([OH:17])=[C:13]([O:18][CH3:19])[CH:12]=2)=C(F)C(F)=C(F)C=1F.[C:25]1([C:31]2[CH:32]=[C:33]([CH:35]=[CH:36][CH:37]=2)[NH2:34])[CH2:30][CH2:29][CH2:28][CH2:27][CH:26]=1>C(OCC)(=O)C>[C:25]1([C:31]2[CH:32]=[C:33]([NH:34][C:9](=[O:20])[CH2:10][C:11]3[CH:16]=[CH:15][C:14]([OH:17])=[C:13]([O:18][CH3:19])[CH:12]=3)[CH:35]=[CH:36][CH:37]=2)[CH2:30][CH2:29][CH2:28][CH2:27][CH:26]=1

Komponenten

4

Edukt 2

HCID 67097493-(Cyclohexen-1-yl)anilineHCID 225073804-Hydroxy-3-methoxyphenylacetic acid pentafluorophenyl ester

Produkt 1

HCID 22019669N-[3-(cyclohexen-1-yl)phenyl]-4-hydroxy-3-methoxyphenylacetamideAusbeute 86 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8857Ethyl AcetateLösungsmittel

Reaktionsbedingungen

Temperatur
60 °C

Versuchsvorschrift

4-Hydroxy-3-methoxyphenylacetic acid pentafluorophenyl ester (60 mg) and Intermediate 2 (60 mg) are dissolved in ethyl acetate, and the mixture is stirred at 60° C. for 18 hours. The solvent is evaporated under reduced pressure, and the residue is purified by silica gel column chromatography (eluent: gradient from 0% to 100% hexane/ethyl acetate) to give the title compound (50 mg).

Aufarbeitung

  1. customThe solvent is evaporated under reduced pressure
  2. customthe residue is purified by silica gel column chromatography (eluent: gradient from 0% to 100% hexane/ethyl acetate)

Quellen und Nachweise

ORD-Eintrag
ord-cd1c80ce4ddb43ffb41ba233536d3992
Quelldatensatz
uspto-grants-2006_08
Patentnummer
US07084176B2

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