N-bromobutanimide → HCID 178498689, Verbindung

HRID 706581Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 706581
[CH3:1][O:2][C:3]([C:5]1[C:6]2[CH:7]=[N:8][NH:9][C:10]=2[CH:11]=[CH:12][C:13]=1[F:14])=[O:4].[Br:15]N1C(=O)CCC1=O>CN(C=O)C>[Br:15][C:7]1[C:6]2[C:5]([C:3]([O:2][CH3:1])=[O:4])=[C:13]([F:14])[CH:12]=[CH:11][C:10]=2[NH:9][N:8]=1

Komponenten

4

Edukt 2

HCID 67184N-bromobutanimideHCID 593345601383474-59-6

Produkt 1

HCID 178498689HCID 178498689, VerbindungAusbeute 69 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

To a solution of methyl-5-fluoro-1H-indazole-4-carboxylate (0.475 g, 2.45 mmol) in 25 mL of DMF was added N-bromosuccinimide (0.566 g, 3.18 mmol). This mixture was stirred at ambient temperature for one hour, then quenched with water. This mixture was extracted with EtOAc, and the combined organic extracts washed with brine, dried over sodium sulfate and concentrated under reduced pressure. Column chromatography (1:1 EtOAc/Hexane) afforded 0.459 g (69%) of the title compound.

Aufarbeitung

  1. customquenched with water
  2. extractionThis mixture was extracted with EtOAc
  3. washthe combined organic extracts washed with brine
  4. dry with materialdried over sodium sulfate
  5. concentrationconcentrated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-acba70997fb7495e8c4fe10424b11020
Quelldatensatz
uspto-grants-2015_11
Patentnummer
US09174981B2

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