Trifluoroacetic acid → 3-Cyclopropyl-6-[[4-(cyclopropylsulfonyl)phenyl](2,4-di fluorophenoxy)methyl]pyridin-2(1H)-one

HRID 70717Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 70717
FC(F)(F)C(O)=O.[CH:8]1([C:11]2[C:12]([O:39]CC3C=CC(OC)=CC=3)=[N:13][C:14]([CH:17]([C:27]3[CH:32]=[CH:31][C:30]([S:33]([CH:36]4[CH2:38][CH2:37]4)(=[O:35])=[O:34])=[CH:29][CH:28]=3)[O:18][C:19]3[CH:24]=[CH:23][C:22]([F:25])=[CH:21][C:20]=3[F:26])=[CH:15][CH:16]=2)[CH2:10][CH2:9]1>C(Cl)(Cl)Cl>[CH:8]1([C:11]2[C:12](=[O:39])[NH:13][C:14]([CH:17]([C:27]3[CH:28]=[CH:29][C:30]([S:33]([CH:36]4[CH2:38][CH2:37]4)(=[O:35])=[O:34])=[CH:31][CH:32]=3)[O:18][C:19]3[CH:24]=[CH:23][C:22]([F:25])=[CH:21][C:20]=3[F:26])=[CH:15][CH:16]=2)[CH2:9][CH2:10]1

Komponenten

4

Edukt 2

HCID 6422Trifluoroacetic acidHCID 673995783-Cyclopropyl-6-{[4-(cyclopropylsulfonyl)phenyl](2,4-difluorophenoxy)methyl}-2-[(4-methoxybenzyl)oxy]pyridine

Produkt 1

HCID 584523163-Cyclopropyl-6-[[4-(cyclopropylsulfonyl)phenyl](2,4-di fluorophenoxy)methyl]pyridin-2(1H)-oneAusbeute 74,4 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6212ChloroformLösungsmittel

Versuchsvorschrift

Trifluoroacetic acid (50 mg) was added to a solution of 3-cyclopropyl-6-{[4-(cyclopropylsulfonyl)phenyl](2,4-difluorophenoxy)methyl}-2-[(4-methoxybenzyl)oxy]pyridine (90 mg) in chloroform (5 mL), and the mixture was stirred at room temperature for two hours. The reaction solution was concentrated under reduced pressure. The resulting residue was purified by silica gel column chromatography (hexane:ethyl acetate=88:12→0:100) to give the title compound as a yellow powder (53 mg, 74%).

Aufarbeitung

  1. concentrationThe reaction solution was concentrated under reduced pressure
  2. customThe resulting residue was purified by silica gel column chromatography (hexane:ethyl acetate=88:12→0:100)

Quellen und Nachweise

ORD-Eintrag
ord-f6090705c34d44e294452ccad8fe1e87
Quelldatensatz
uspto-grants-2014_09
Patentnummer
US08822503B2

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