Hydrochloric Acid → HCID 178479283, Verbindung
Reaktionsgleichung
C(OC(=O)[NH:7][C@H:8]1[CH2:11][C@H:10]([N:12]2[C:16]3=[N:17][CH:18]=[C:19]([Br:21])[N:20]=[C:15]3[N:14]([CH:22]3[CH2:24][CH2:23]3)[C:13]2=[O:25])[CH2:9]1)(C)(C)C.[ClH:27]>O1CCOCC1>[ClH:27].[NH2:7][C@H:8]1[CH2:11][C@H:10]([N:12]2[C:16]3=[N:17][CH:18]=[C:19]([Br:21])[N:20]=[C:15]3[N:14]([CH:22]3[CH2:23][CH2:24]3)[C:13]2=[O:25])[CH2:9]1Komponenten
4
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
To a room temperature slurry of tert-butyl(trans-3-(5-bromo-3-cyclopropyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyrazin-1-yl)cyclobutyl)carbamate (0.556 g, 1.31 mmol) in dioxane (10 mL) was added hydrogen chloride, 4.0M solution in 1,4-dioxane (5.0 mL, 20.00 mmol). After stirring overnight the reaction was filtered and the precipitate was washed with Et2O to give 430 mg of a white amorphous solid. ESI MS 323.9, 325.9 [M+1].