N-chlorosuccinamide → Pyridine-2-carboximidoyl chloride
Reaktionsgleichung
C([C:3]1[C:4]([CH:9]=[N:10]O)=[N:5][CH:6]=[CH:7][CH:8]=1)C.[Cl:12]NC(=O)CCC(N)=O>CN(C=O)C>[N:5]1[CH:6]=[CH:7][CH:8]=[CH:3][C:4]=1[C:9]([Cl:12])=[NH:10]Komponenten
4
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Reaktionsbedingungen
- Temperatur
- 30 °C
Versuchsvorschrift
To a mixture of ethyl 2-pyridin-aldoxime (15 gm) and N-chlorosuccinamide (25 gm) in DMF (30 ml) was stirred at 30° C. over a period of 2 h. The reaction mixture was quenched with ice-cold water (150 ml). The suspension was filtered and the wet cake washed with small quantity of water to provide pure title compound in 7 gm quantity (55%) as a white solid.
Aufarbeitung
- customThe reaction mixture was quenched with ice-cold water (150 ml)
- filtrationThe suspension was filtered
- washthe wet cake washed with small quantity of water
Quellen und Nachweise
- ORD-Eintrag
- ord-b8551bfae5ee4eb1a2fb451ddede6637
- Quelldatensatz
- uspto-grants-2015_11
- Patentnummer
- US09175031B2
Notizen zur Reaktion
Wird geladen…