Phosphoric Acid → Codeinone 14-Hydroxycodeinone

HRID 70777

Reaktionsgleichung

[CH3:1][N:2]1[C@@H:19]2[CH2:20][C:7]3[CH:8]=[CH:9][C:10]([O:21][CH3:22])=[C:11]4[O:12][C@H:13]5[C:14]([CH:16]=[CH:17][C@@H:18]2[C@:5]5([C:6]=34)[CH2:4][CH2:3]1)=[O:15].[CH3:23][N:24]1[C@@H:34]2[CH2:35][C:36]3[CH:41]=[CH:40][C:39]([O:42][CH3:43])=[C:38]4[O:44][CH:28]5[C:29]([CH:31]=[CH:32][C@:33]2([OH:45])[C@:27]5([C:37]=34)[CH2:26][CH2:25]1)=[O:30].P(=O)(O)(O)O>>[CH3:1][N:2]1[C@@H:19]2[CH2:20][C:7]3[CH:8]=[CH:9][C:10]([O:21][CH3:22])=[C:11]4[O:12][C@H:13]5[C:14]([CH:16]=[CH:17][C@@H:18]2[C@:5]5([C:6]=34)[CH2:4][CH2:3]1)=[O:15].[CH3:23][N:24]1[C@@H:34]2[CH2:35][C:36]3[CH:41]=[CH:40][C:39]([O:42][CH3:43])=[C:38]4[O:44][CH:28]5[C:29]([CH:31]=[CH:32][C@:33]2([OH:45])[C@:27]5([C:37]=34)[CH2:26][CH2:25]1)=[O:30]

Komponenten

Edukt 3

HCID 1004Phosphoric Acid

HCID 5359420(4R,4aS,12bS)-4a-hydroxy-9-methoxy-3-methyl-2,4,7a,13-tetrahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7-one

HCID 5459910Codeinone

Produkt 1

HCID 131726012Codeinone 14-Hydroxycodeinone

Versuchsvorschrift

25±1 mg of both codeinone and 14-hydroxycodeinone reference materials were weighed and transferred into a 100-mL volumetric flask, diluted to volume and dissolved with ˜0.85% phosphoric acid solution II.

Aufarbeitung

customtransferred into a 100-mL volumetric flask
additiondiluted to volume

Quellen und Nachweise

ORD-Eintrag: ord-035af55de6134fabbd797eb93ee1d4e8
Quelldatensatz: uspto-grants-2014_09
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US08822687B2

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