Phosphoric Acid → Codeinone 14-Hydroxycodeinone
Reaktionsgleichung
[CH3:1][N:2]1[C@@H:19]2[CH2:20][C:7]3[CH:8]=[CH:9][C:10]([O:21][CH3:22])=[C:11]4[O:12][C@H:13]5[C:14]([CH:16]=[CH:17][C@@H:18]2[C@:5]5([C:6]=34)[CH2:4][CH2:3]1)=[O:15].[CH3:23][N:24]1[C@@H:34]2[CH2:35][C:36]3[CH:41]=[CH:40][C:39]([O:42][CH3:43])=[C:38]4[O:44][CH:28]5[C:29]([CH:31]=[CH:32][C@:33]2([OH:45])[C@:27]5([C:37]=34)[CH2:26][CH2:25]1)=[O:30].P(=O)(O)(O)O>>[CH3:1][N:2]1[C@@H:19]2[CH2:20][C:7]3[CH:8]=[CH:9][C:10]([O:21][CH3:22])=[C:11]4[O:12][C@H:13]5[C:14]([CH:16]=[CH:17][C@@H:18]2[C@:5]5([C:6]=34)[CH2:4][CH2:3]1)=[O:15].[CH3:23][N:24]1[C@@H:34]2[CH2:35][C:36]3[CH:41]=[CH:40][C:39]([O:42][CH3:43])=[C:38]4[O:44][CH:28]5[C:29]([CH:31]=[CH:32][C@:33]2([OH:45])[C@:27]5([C:37]=34)[CH2:26][CH2:25]1)=[O:30]Komponenten
4
Versuchsvorschrift
25±1 mg of both codeinone and 14-hydroxycodeinone reference materials were weighed and transferred into a 100-mL volumetric flask, diluted to volume and dissolved with ˜0.85% phosphoric acid solution II.