Ethanol → Ethyl 2-(2-oxocyclopentyl)acetate

To a solution of 2-(2-oxocyclopentyl)acetic acid (23.6 g, 166 mmol) in absolute ethanol (400 mL) was added H2SO4 (16.28 g, 166 mmol). The resultant solution was heated under reflux overnight. The reaction mixture was concentrated and the liquid residue was added into ice-water (200 mL). The aqueous mixture was extracted with DCM (3×200 mL). The combined organic layers were washed with H2O (300 mL), brine (300 mL), dried over Na2SO4, decanted, concentrated and dried under vacuum to afford the title compound as a light yellow liquid (27.2 g). LCMS m/z=171.3 [M+H]; 1H NMR (400 MHz, CDCl3) δ ppm 1.19 (t, J=7.14 Hz, 3H), 1.50-1.62 (m, 1H), 1.65-1.80 (m, 1H), 1.92-2.02 (m, 1H), 2.12 (dd, J=16.7, 8.86 Hz, 1H), 2.19-2.29 (m, 2H), 2.30-2.44 (m, 2H), 2.65 (dd, J=15.12, 2.6 Hz, 1H), 4.07 (q, J=7.14 Hz, 2H).

1. temperatureunder reflux overnight
2. concentrationThe reaction mixture was concentrated
3. additionthe liquid residue was added into ice-water (200 mL)
4. extractionThe aqueous mixture was extracted with DCM (3×200 mL)
5. washThe combined organic layers were washed with H2O (300 mL), brine (300 mL)
6. dry with materialdried over Na2SO4
7. customdecanted
8. concentrationconcentrated
9. customdried under vacuum

ORD-Eintrag

ord-3b16814528f14113b0e706208d208b29

Quelldatensatz

uspto-grants-2015_11

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US09175320B2