Oxetan-3-amine hydrochloride → 2-[5-Amino-2-(2,4-difluoro-phenyl)-2H-[1,2,4]triazol-3-yl]-4,5-dihydro-6-oxa-1-thia-benzo[e]azulene-8-carboxylic acid oxetan-3-ylamide

HRID 708042

Reaktionsgleichung

Reaktionsgleichung von HRID 708042
[NH2:1][C:2]1[N:3]=[C:4]([C:15]2[S:24][C:23]3[C:22]4[CH:25]=[CH:26][C:27]([C:29](O)=[O:30])=[CH:28][C:21]=4[O:20][CH2:19][CH2:18][C:17]=3[CH:16]=2)[N:5]([C:7]2[CH:12]=[CH:11][C:10]([F:13])=[CH:9][C:8]=2[F:14])[N:6]=1.Cl.[NH2:33][CH:34]1[CH2:37][O:36][CH2:35]1>>[O:36]1[CH2:37][CH:34]([NH:33][C:29]([C:27]2[CH:26]=[CH:25][C:22]3[C:23]4[S:24][C:15]([C:4]5[N:5]([C:7]6[CH:12]=[CH:11][C:10]([F:13])=[CH:9][C:8]=6[F:14])[N:6]=[C:2]([NH2:1])[N:3]=5)=[CH:16][C:17]=4[CH2:18][CH2:19][O:20][C:21]=3[CH:28]=2)=[O:30])[CH2:35]1

Komponenten

3

Edukt 2

HCID 23062080Oxetan-3-amine hydrochlorideHCID 670505382-[5-Amino-2-(2,4-difluoro-phenyl)-2H-[1,2,4]triazol-3-yl]-4,5-dihydro-6-oxa-1-thia-benzo[e]azulene-8-carboxylic acid

Produkt 1

HCID 582040582-[5-Amino-2-(2,4-difluoro-phenyl)-2H-[1,2,4]triazol-3-yl]-4,5-dihydro-6-oxa-1-thia-benzo[e]azulene-8-carboxylic acid oxetan-3-ylamide

Versuchsvorschrift

Similarly to as described in General Procedure D, 2-[5-Amino-2-(2,4-difluoro-phenyl)-2H-[1,2,4]triazol-3-yl]-4,5-dihydro-6-oxa-1-thia-benzo[e]azulene-8-carboxylic acid was reacted with 3-aminooxetane hydrochloride to give 297 as a colorless solid after reverse phase HPLC (146 mg). LCMS: 496.1

Quellen und Nachweise

ORD-Eintrag
ord-f5325691ea674035874aee9f34b2c4b1
Quelldatensatz
uspto-grants-2015_11
Patentnummer
US09175009B2

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