Sodium Hydroxide → HCID 178524643, Verbindung

HRID 70898Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 70898
[OH:1][C:2]1[CH:6]=[C:5]([C:7]([O:9]C)=[O:8])[S:4][N:3]=1.[OH-].[Na+]>CO>[OH:1][C:2]1[CH:6]=[C:5]([C:7]([OH:9])=[O:8])[S:4][N:3]=1

Komponenten

4

Edukt 2

HCID 14798Sodium HydroxideHCID 178498604HCID 178498604, Verbindung

Produkt 1

HCID 178524643HCID 178524643, VerbindungAusbeute 99,6 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

To a solution of methyl 3-hydroxyisothiazole-5-carboxylate (300 mg, 1.73 mmol) in MeOH (2 mL) is added 1N NaOH (6 mL, 6 mmol). After stirring at room temperature for 2 hours, the crude is concentrated under reduced pressure to remove MeOH and is diluted with EtOAc. The organic layer is washed with brine, dried over Na2SO4, filtered and concentrated under reduced pressure to give 3-hydroxyisothiazole-5-carboxylic acid (250 mg).

Aufarbeitung

  1. concentrationthe crude is concentrated under reduced pressure
  2. customto remove MeOH
  3. additionis diluted with EtOAc
  4. washThe organic layer is washed with brine
  5. dry with materialdried over Na2SO4
  6. filtrationfiltered
  7. concentrationconcentrated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-678f4bf1923a48c7820e53ed6a2bdcf2
Quelldatensatz
uspto-grants-2014_09
Patentnummer
US08822534B2

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