Potassium Iodide → Methyl {3-(4-chlorophenyl)-5-oxo-4-(3,3,3-trifluoro-2-hydroxypropyl)-4,5-dihydro-1H-1,2,4-triazol-1-yl}acetate

3.04 g (9.9 mmol) of the compound of Example 4A were dissolved in 100 ml of acetonitrile, and 1.07 g (9.9 mmol) of methyl chloroacetate, 2.73 g (19.8 mmol) of potassium carbonate and a small spatula tip of potassium iodide were added. The reaction mixture was heated at reflux for 1 h, allowed to cool to RT and filtered. The filtrate was freed from the volatile components on a rotary evaporator and the residue was dried under high vacuum. This gave 3.70 g of the title compound in a purity of about 90% (89% of theory).

1. temperatureThe reaction mixture was heated
2. temperatureat reflux for 1 h
3. filtrationfiltered
4. customThe filtrate was freed from the volatile components on a rotary evaporator
5. customthe residue was dried under high vacuum

ORD-Eintrag

ord-77d803ea036b4ae6af8dfa4d9fbed6ab

Quelldatensatz

uspto-grants-2015_11

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US09180120B2