(2R)-4-(4-iodo-2-oxopyridin-1(2H)-yl)-2-methyl-2-(methylsulfonyl)-N-[(2R)-tetrahydro-2H-pyran-2-yloxy]butanamide → HCID 178448467, Verbindung
Reaktionsgleichung
IC1C=CN(CC[C@@](C)(S(C)(=O)=O)C(NO[C@@H]2CCCCO2)=O)C(=O)C=1.CC1(C)C(C)(C)OB(C2C=CC(OC[C@H]3CC[C@H](OC4CCCCO4)CC3)=CC=2)O1.[CH3:57][C@@:58]([S:99]([CH3:102])(=[O:101])=[O:100])([CH2:69][CH2:70][N:71]1[CH:76]=[CH:75][C:74]([C:77]2[CH:82]=[CH:81][C:80]([O:83][CH2:84][C@H:85]3[CH2:90][CH2:89][C@@H:88]([O:91][CH:92]4[CH2:97][CH2:96][CH2:95][CH2:94][O:93]4)[CH2:87][CH2:86]3)=[CH:79][CH:78]=2)=[CH:73][C:72]1=[O:98])[C:59]([NH:61][O:62][CH:63]1[CH2:68][CH2:67][CH2:66][CH2:65][O:64]1)=[O:60]>>[CH3:57][C@@:58]([S:99]([CH3:102])(=[O:100])=[O:101])([CH2:69][CH2:70][N:71]1[CH:76]=[CH:75][C:74]([C:77]2[CH:82]=[CH:81][C:80]([O:83][CH2:84][C@H:85]3[CH2:90][CH2:89][C@H:88]([O:91][CH:92]4[CH2:97][CH2:96][CH2:95][CH2:94][O:93]4)[CH2:87][CH2:86]3)=[CH:79][CH:78]=2)=[CH:73][C:72]1=[O:98])[C:59]([NH:61][O:62][CH:63]1[CH2:68][CH2:67][CH2:66][CH2:65][O:64]1)=[O:60]Komponenten
4
Versuchsvorschrift
The title compound (489 mg, 49.7%) was prepared from (2R)-4-(4-iodo-2-oxopyridin-1(2H)-yl)-2-methyl-2-(methylsulfonyl)-N-[(2R)-tetrahydro-2H-pyran-2-yloxy]butanamide (742 mg, 1.49 mmol) and 2-[(trans-4-{[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy]methyl}cyclohexyl)oxy]tetrahydro-2H-pyran (620 mg, 1.49 mmol) by a procedure analogous to that described for (2R)-2-methyl-2-(methylsulfonyl)-4-[2-oxo-4-(4-{[cis-4-(tetrahydro-2H-pyran-2-yloxy)cyclohexyl]methoxy}phenyl)pyridin-1(2H)-yl]-N-(tetrahydro-2H-pyran-2-yloxy)butanamide, Example 8, Step E. LCMS m/z 659.8 (M−1).
Quellen und Nachweise
- ORD-Eintrag
- ord-65c801d28e734e578c44f0310d3dfbfc
- Quelldatensatz
- uspto-grants-2015_11
- Patentnummer
- US09180123B2
Notizen zur Reaktion
Wird geladen…