Reaktionsgleichung
[NH2:1][C:2]([CH3:16])([CH2:5][N:6]1[N:10]=[C:9]2[CH:11]=[CH:12][C:13]([CH3:15])=[CH:14][C:8]2=[N:7]1)[C:3]#[N:4].[F:17][C:18]([F:29])([F:28])[C:19]1[CH:27]=[CH:26][C:22]([C:23](Cl)=[S:24])=[CH:21][CH:20]=1>>[C:3]([C:2]([NH:1][C:23](=[S:24])[C:22]1[CH:21]=[CH:20][C:19]([C:18]([F:17])([F:28])[F:29])=[CH:27][CH:26]=1)([CH3:16])[CH2:5][N:6]1[N:10]=[C:9]2[CH:11]=[CH:12][C:13]([CH3:15])=[CH:14][C:8]2=[N:7]1)#[N:4]Komponenten
3
Versuchsvorschrift
Using a procedure similar to that described in Example 1, except using 2-amino-2-methyl-3-(5-methyl-2H-benzotriazol-2-yl)propionitrile, described in Example 7, and 4-trifluoromethylthiobenzoyl chloride, the title compound was isolated as a white solid (0.12 g, 57%). Rf=0.65 (1:1 EA/heptane). MS (ES): M/Z [M+H]=420. 1H NMR: (400 MHz, DMSO-d6): 1.73 (s, 3H), 2.45 (s, 3H), 5.34-5.44 (m, 2H), 7.30 (dd, J=8.8, 1.4 Hz, 1H), 7.68 (d, J=1.0 Hz, 1H), 7.82 (d, J=8.8 Hz, 1H), 7.84-7.94 (m, 4H) and 8.91 (s, 1H). 19F NMR (376 MHz, DMSO-d6): −41.94 (s, 3F).
Quellen und Nachweise
- ORD-Eintrag
- ord-64488f60826f440bb8e8f90885f54020
- Quelldatensatz
- uspto-grants-2014_09
- Patentnummer
- US08822689B2
Verknüpfte Notizen
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