Hydrogen Bromide → 1-(2-Bromoethyl)-4-chlorobenzene
Reaktionsgleichung
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8](O)[CH3:9])=[CH:4][CH:3]=1.[BrH:11]>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][Br:11])=[CH:4][CH:3]=1Komponenten
3
Versuchsvorschrift
In a 65 mL glass pressure vessel, 4-chlorophenylethanol (32.725 g, 209 mmol) was warmed to between 90 and 100° C. The vessel was charged with hydrogen bromide gas and the mixture was stirred at +1.38 to +1.93 bar for 4.5 h. The pressure was released and the reaction showed 99.18% conversion by HPLC. The mixture was allowed to cool to room temperature to leave 2-(4-chlorophenyl)ethyl bromide as a brown liquid (53.735 g).
Quellen und Nachweise
- ORD-Eintrag
- ord-4d1a51bd11334accb7757aef65b5f025
- Quelldatensatz
- uspto-grants-2014_09
- Patentnummer
- US08822727B2
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