Chlorosuccinimide → HCID 178506300, Verbindung

HRID 710649

Reaktionsgleichung

[F:1][C:2]([F:9])([F:8])[C:3]1[CH:7]=[CH:6][NH:5][N:4]=1.C1C(=O)N([Cl:17])C(=O)C1>CC#N>[Cl:17][C:7]1[C:3]([C:2]([F:9])([F:8])[F:1])=[N:4][NH:5][CH:6]=1

Komponenten

Reaktionsbedingungen

Temperatur: 80 °C

Versuchsvorschrift

A mixture of 3-(trifluoromethyl)pyrazole (1.58 g, 11.6 mmol) and NCS (1.55 g, 11.6 mmol) in CH3CN (20 mL) was heated at 80° C. for 3 hrs. It was then cooled to rt, evaporated in vacuo, and purified by flash chromatography (SiO2) with a gradient elution of 0 to 15% EtOAc/CH2Cl2 to afford 4-chloro-3-(trifluoromethyl)pyrazole (1.52 g, 77%).

Aufarbeitung

temperatureIt was then cooled to rt
customevaporated in vacuo
custompurified by flash chromatography (SiO2) with a gradient elution of 0 to 15% EtOAc/CH2Cl2

Quellen und Nachweise

ORD-Eintrag: ord-68aec33ad7dd4055a0d2ae5214264e52
Quelldatensatz: uspto-grants-2015_11
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US09181241B2

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