Hydrochloric Acid → HCID 178497304, Verbindung

HRID 711087Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 711087
[O:1]=[C:2]1[C:10]2[C:5](=[CH:6][C:7]([C:11]([OH:13])=[O:12])=[CH:8][CH:9]=2)[NH:4][NH:3]1.Cl.[CH3:15]O>>[OH:1][C:2]1[C:10]2[C:5](=[CH:6][C:7]([C:11]([O:13][CH3:15])=[O:12])=[CH:8][CH:9]=2)[NH:4][N:3]=1

Komponenten

4

Edukt 3

HCID 313Hydrochloric AcidHCID 887MethanolHCID 533377172,3-Dihydro-3-oxo-1H-indazole-6-carboxylic acid

Produkt 1

HCID 178497304HCID 178497304, VerbindungAusbeute 100 %

Versuchsvorschrift

3-Oxo-2,3-dihydro-1H-indazole-6-carboxylic acid (1.5 g, 8.4 mmol) was suspended in methanol (17 mL). Concentrated hydrochloric acid (3.1 mL, 101 mmol) was added and the reaction was heated to reflux for 24 hours. The reaction was concentrated to give the title compound (1.6 g, 100%). +ESI (M+H) 193.1; 1H NMR (400 MHz, DMSO-d6, δ): 11.98 (br. s., 1H), 7.89 (s, 1H), 7.72 (d, J=8.6 Hz, 1H), 7.50 (dd, J=8.5, 1.3 Hz, 1H), 3.85 (s, 3H).

Aufarbeitung

  1. temperaturethe reaction was heated
  2. temperatureto reflux for 24 hours
  3. concentrationThe reaction was concentrated

Quellen und Nachweise

ORD-Eintrag
ord-ff20ba9906f44c66b1331711b9a4ab7b
Quelldatensatz
uspto-grants-2015_11
Patentnummer
US09181252B2

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