m-Chloroperbenzoic acid → HCID 67400511, Verbindung

HRID 711712Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 711712
[S:1]([NH:5][C:6]1[CH:13]=[CH:12][CH:11]=[C:10]([S:14][CH3:15])[C:7]=1[C:8]#[N:9])(=[O:4])(=[O:3])[NH2:2].C1C=C(Cl)C=C(C(OO)=[O:24])C=1>ClCCl>[S:1]([NH:5][C:6]1[CH:13]=[CH:12][CH:11]=[C:10]([S:14]([CH3:15])=[O:24])[C:7]=1[C:8]#[N:9])(=[O:3])(=[O:4])[NH2:2]

Komponenten

4

Edukt 2

HCID 70297m-Chloroperbenzoic acidHCID 67400359HCID 67400359, Verbindung

Produkt 1

HCID 67400511HCID 67400511, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

The mixture of 2-sulfamoylamino-6-(methylthio)benzonitrile (Example 104a) (48 mg, 0.2 mmol) and MCPBA (69 mg, 0.4 mmol) in dichloromethane (16 mL) was heated refluxed overnight. After cooling down, the precipitation was collected by filtration, rinsed with dichloromethane, dried in the air to give the title compound. 1H NMR (400 MHz, DMSO-d6) δ 2.83 (s, 3H), 7.35 (brs, 2H), 7.72-6.69 (m, 2H), 7.92 (t, J=8.0 Hz, 1H), 9.87 (brs, 1H).

Aufarbeitung

  1. temperaturewas heated
  2. temperaturerefluxed overnight
  3. temperatureAfter cooling down
  4. customthe precipitation
  5. filtrationwas collected by filtration
  6. washrinsed with dichloromethane
  7. customdried in the air

Quellen und Nachweise

ORD-Eintrag
ord-d4acf21124534927996937eaf6263efc
Quelldatensatz
uspto-grants-2015_11
Patentnummer
US09181276B2

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