Acetyl chloride → 3-(2-Cyano-3-nitrophenoxy)-2-methylpropyl acetate
Reaktionsgleichung
[OH:1][CH2:2][CH:3]([CH3:17])[CH2:4][O:5][C:6]1[CH:13]=[CH:12][CH:11]=[C:10]([N+:14]([O-:16])=[O:15])[C:7]=1[C:8]#[N:9].[C:18](Cl)(=[O:20])[CH3:19]>>[C:18]([O:1][CH2:2][CH:3]([CH3:17])[CH2:4][O:5][C:6]1[CH:13]=[CH:12][CH:11]=[C:10]([N+:14]([O-:16])=[O:15])[C:7]=1[C:8]#[N:9])(=[O:20])[CH3:19]Komponenten
3
Versuchsvorschrift
Prepared as in Example 231c from 2-(3-hydroxy-2-methylpropoxy)-6-nitrobenzonitrile (Example 237d) and acetyl chloride in 41% yield. 1H NMR (400 MHz, DMSO-d6) δ 1.04 (d, J=6.8 Hz, 3H), 2.00 (s, 3H), 2.28-2.33 (m, 1H), 4.05-4.08 (m, 2H), 4.18 (d, J=6.0 Hz, 2H), 7.71-7.73 (m, 1H), 7.86-7.92 (m, 2H).
Quellen und Nachweise
- ORD-Eintrag
- ord-39ed75c20e9a4799b2e20f289049998f
- Quelldatensatz
- uspto-grants-2015_11