1,4-Dioxane hydrochloride → Ethyl 4-cyanopiperidine-4-carboxylate hydrochloride

HRID 712208

Reaktionsgleichung

Reaktionsgleichung von HRID 712208
[C:1]([C:3]1([C:16]([O:18][CH2:19][CH3:20])=[O:17])[CH2:8][CH2:7][N:6](C(OC(C)(C)C)=O)[CH2:5][CH2:4]1)#[N:2].[ClH:21].O1CCOCC1>O1CCOCC1>[ClH:21].[C:1]([C:3]1([C:16]([O:18][CH2:19][CH3:20])=[O:17])[CH2:8][CH2:7][NH:6][CH2:5][CH2:4]1)#[N:2]

Komponenten

4

Edukt 2

HCID 204431481,4-Dioxane hydrochlorideHCID 577503761-tert-Butyl 4-ethyl 4-cyanopiperidine-1,4-dicarboxylate

Produkt 1

HCID 14294360Ethyl 4-cyanopiperidine-4-carboxylate hydrochloride

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 312751,4-DioxaneLösungsmittel

Versuchsvorschrift

To an ice-cold solution of O1-tert-butyl O4-ethyl 4-cyanopiperidine-1,4-dicarboxylate (0.4 g, 1.41 mmol) in 1,4-dioxane (10 mL) was added HCl-dioxane (4 M, 5 mL) solution. The resulting mixture was stirred at rt for 30 minutes. After completion of reaction (by TLC), solvent was evaporated to obtain the product as a solid (0.28 g). MS: 183.27 [M+H]+.

Aufarbeitung

  1. customAfter completion of reaction (by TLC), solvent
  2. customwas evaporated

Quellen und Nachweise

ORD-Eintrag
ord-34de48a7e7044ab0bc5ba72bcaffcbd0
Quelldatensatz
uspto-grants-2015_11
Patentnummer
US09181234B2

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