Methanol → Methyl 4-hydroxypiperidine-4-carboxylate

HRID 712212Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 712212
C([N:8]1[CH2:13][CH2:12][C:11]([OH:17])([C:14]([OH:16])=[O:15])[CH2:10][CH2:9]1)C1C=CC=CC=1.[CH3:18]O>[OH-].[Pd+2].[OH-]>[OH:17][C:11]1([C:14]([O:16][CH3:18])=[O:15])[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]1

Komponenten

4

Edukt 2

HCID 887MethanolHCID 203941814-Piperidinecarboxylicacid, 4-hydroxy-1-(phenylmethyl)-

Produkt 1

HCID 21093366Methyl 4-hydroxypiperidine-4-carboxylate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 9942167Palladium hydroxideKatalysator

Versuchsvorschrift

To a stirred solution of 1-benzyl-4-hydroxypiperidine-4-carboxylic acid (1.2 g, 5.1 mmol) in MeOH (15 mL) was added palladium hydroxide and the resulting mixture was stirred at rt for 6 h under H2 atmosphere. After completion (by TLC), the mixture was passed through celite and the filtrate evaporated under reduced pressure. The crude (1 g) residue was carried forward to the next step without further purification. MS: 160.18 [M+H]+.

Aufarbeitung

  1. customthe filtrate evaporated under reduced pressure
  2. customThe crude (1 g) residue was carried forward to the next step without further purification

Quellen und Nachweise

ORD-Eintrag
ord-11ecec35c18a44528df52b212433cdca
Quelldatensatz
uspto-grants-2015_11
Patentnummer
US09181234B2

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