1,4-Dioxane hydrochloride → Ethyl 4-Fluoropiperidine-4-carboxylate Hydrochloride

HRID 712220Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 712220
[F:1][C:2]1([C:15]([O:17][CH2:18][CH3:19])=[O:16])[CH2:7][CH2:6][N:5](C(OC(C)(C)C)=O)[CH2:4][CH2:3]1.[ClH:20].O1CCOCC1>O1CCOCC1>[ClH:20].[F:1][C:2]1([C:15]([O:17][CH2:18][CH3:19])=[O:16])[CH2:3][CH2:4][NH:5][CH2:6][CH2:7]1

Komponenten

4

Edukt 2

HCID 204431481,4-Dioxane hydrochlorideHCID 21306965Ethyl N-Boc-4-fluoropiperidine-4-carboxylate

Produkt 1

HCID 24729616Ethyl 4-Fluoropiperidine-4-carboxylate Hydrochloride

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 312751,4-DioxaneLösungsmittel

Versuchsvorschrift

To an ice-cold solution of 1-tert-butyl 4-ethyl 4-fluoropiperidine-1,4-dicarboxylate (1.0 g, 3.89 mmol) in 1,4-dioxane (10 mL) was added HCl-dioxane (4.0 M, 15 mL) solution and the mixture stirred at rt for 30 min. After completion of reaction (By TLC), solvent was evaporated to obtain brownish solid material (0.78 g) that was carried forward to the next step without purification. MS: 176.20 [M+H]+.

Aufarbeitung

  1. customAfter completion of reaction (By TLC), solvent
  2. customwas evaporated

Quellen und Nachweise

ORD-Eintrag
ord-66adb15eb9754d9baab078a1ad65a9f1
Quelldatensatz
uspto-grants-2015_11
Patentnummer
US09181234B2

Notizen zur Reaktion

Wird geladen…