4-Piperidinecarboxylicacid, 4-hydroxy-1-(phenylmethyl)- → 4-hydroxypiperidine-4-carboxylic Acid
Reaktionsgleichung
C([N:8]1[CH2:13][CH2:12][C:11]([OH:17])([C:14]([OH:16])=[O:15])[CH2:10][CH2:9]1)C1C=CC=CC=1>CCO.[OH-].[Pd+2].[OH-]>[OH:17][C:11]1([C:14]([OH:16])=[O:15])[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]1Komponenten
4
Edukt 1
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 2
Versuchsvorschrift
To the solution of 1-benzyl-4-hydroxypiperidine-4-carboxylic acid (1.0 g, 4.25 mmol) in EtOH (15.0 mL) was added palladium hydroxide (0.40 g, 40% w/w) at rt and the mixture stirred at rt for 20 h under H2 atmosphere. After completion of reaction (by TLC) the mixture was passed through celite and the solvent evaporated. The crude (0.70 g) residue was carried forward for next step without further purification. MS: 145.99 [M+H]+.
Aufarbeitung
- customAfter completion of reaction (by TLC) the mixture
- customthe solvent evaporated
- customThe crude (0.70 g) residue was carried forward for next step without further purification
Quellen und Nachweise
- ORD-Eintrag
- ord-a7b19ad20be74b3bba2796b50d0ee09b
- Quelldatensatz
- uspto-grants-2015_11
- Patentnummer
- US09181234B2
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