Hydrochloric Acid → Ethyl 4-hydroxypiperidine-4-carboxylate

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Reaktionsgleichung

[OH:1][C:2]1([C:8]([OH:10])=[O:9])[CH2:7][CH2:6][NH:5][CH2:4][CH2:3]1.Cl.[CH3:12][CH2:13]O>>[OH:1][C:2]1([C:8]([O:10][CH2:12][CH3:13])=[O:9])[CH2:7][CH2:6][NH:5][CH2:4][CH2:3]1

Komponenten

Edukt 3

HCID 313Hydrochloric Acid

HCID 702Ethanol

HCID 44371984-hydroxypiperidine-4-carboxylic Acid

Produkt 1

HCID 22717992Ethyl 4-hydroxypiperidine-4-carboxylate

Reaktionsbedingungen

Temperatur: 80 °C

Versuchsvorschrift

To a solution of 4-hydroxypiperidine-4-carboxylic acid (1.20 g, 8.26 mmol) in EtOH (30 ml) was added conc. HCl (5 ml) at rt and the mixture heated up to 80° C. for 2-3 h. After completion (by TLC), solvent was evaporated under reduced pressure to obtain the desired product (1.20 g, crude) which was carried forward for next step without further purification. 1H NMR (D2O): δ 4.20 (q, J=7.20 Hz, 2H), 3.28 (M, 4H), 2.22 (m, 2H), 1.91 (m, 2H), and 1.22 (t, J=7.20 Hz, 3H).

Aufarbeitung

customAfter completion (by TLC), solvent was evaporated under reduced pressure

Quellen und Nachweise

ORD-Eintrag: ord-be55e4bfe4414e40959400e0b8e12611
Quelldatensatz: uspto-grants-2015_11
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US09181234B2

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