Thionyl Chloride → 4-Chloro-7-methoxyquinazolin-6-yl acetate

HRID 712375Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 712375
[C:1]([O:4][C:5]1[CH:6]=[C:7]2[C:12](=[CH:13][C:14]=1[O:15][CH3:16])[N:11]=[CH:10][NH:9][C:8]2=O)(=[O:3])[CH3:2].S(Cl)([Cl:20])=O>CN(C=O)C>[C:1]([O:4][C:5]1[CH:6]=[C:7]2[C:12](=[CH:13][C:14]=1[O:15][CH3:16])[N:11]=[CH:10][N:9]=[C:8]2[Cl:20])(=[O:3])[CH3:2]

Komponenten

4

Edukt 2

HCID 24386Thionyl ChlorideHCID 1356819606-Acetoxy-7-methoxy-3H-quinazolin-4-one

Produkt 1

HCID 220221604-Chloro-7-methoxyquinazolin-6-yl acetate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Reaktionsbedingungen

Temperatur
70 °C

Versuchsvorschrift

A suspension of 7-methoxy-4-oxo-3,4-dihydroquinazolin-6-yl acetate (2.00 g), DMF (0.20 mL) and thionyl chloride (30 mL) was stirred at 70° C. for 3 h. The mixture was concentrated in vacuo, and the residue was used for the next step without further purification.

Aufarbeitung

  1. concentrationThe mixture was concentrated in vacuo
  2. customthe residue was used for the next step without further purification

Quellen und Nachweise

ORD-Eintrag
ord-a0cb960bfa2a472d98274a925c68df95
Quelldatensatz
uspto-grants-2015_11
Patentnummer
US09181277B2

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