Hydrochloric Acid → Hydrochloric Acid

HRID 713178Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 713178
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([F:23])=[C:6]([CH:22]=1)[C:7]([CH:9]1[CH2:14][CH2:13][N:12](C(OC(C)(C)C)=O)[CH2:11][CH2:10]1)=[O:8].[ClH:24]>O1CCOCC1>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([F:23])=[C:6]([C:7]([CH:9]2[CH2:10][CH2:11][NH:12][CH2:13][CH2:14]2)=[O:8])[CH:22]=1.[ClH:24]

Komponenten

5

Edukt 2

HCID 313Hydrochloric AcidHCID 49761188tert-Butyl 4-(5-chloro-2-fluorobenzoyl)piperidine-1-carboxylate

Produkt 2

HCID 313Hydrochloric AcidAusbeute 475 %HCID 49761187(5-Chloro-2-fluorophenyl)(piperidin-4-yl)methanone

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 312751,4-DioxaneLösungsmittel

Versuchsvorschrift

A solution of tert-butyl 4-(5-chloro-2-fluorobenzoyl)piperidine-1-carboxylate (287.9 mg, 0.843 mmol) in dioxane (2.41 mL) was treated with HCl (2.11 mL, 8.43 mmol) at rt and the resulting reaction mixture was stirred overnight. The reaction mixture was diluted with hexanes and filtered by suction to afford (5-chloro-2-fluorophenyl)(piperidin-4-yl)methanone as its HCl salt (146 mg, 62.3%) as a yellow solid. ESI-MS m/z [M+H]+242.20.

Aufarbeitung

  1. customthe resulting reaction mixture
  2. filtrationfiltered by suction

Quellen und Nachweise

ORD-Eintrag
ord-9d49f41d15444870bf1ce1c65a16e3fa
Quelldatensatz
uspto-grants-2015_11
Patentnummer
US09181249B2

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