Potassium Carbonate → Oxazole, 5-[3-fluoro-4-(trifluoromethyl)phenyl]-

HRID 714052Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 714052
[F:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][C:9]=1[C:10]([F:13])([F:12])[F:11])[CH:5]=[O:6].C1(C)C=CC(S([CH2:23][N+:24]#[C-:25])(=O)=O)=CC=1.C(=O)([O-])[O-].[K+].[K+]>CO>[F:1][C:2]1[CH:3]=[C:4]([C:5]2[O:6][CH:25]=[N:24][CH:23]=2)[CH:7]=[CH:8][C:9]=1[C:10]([F:11])([F:12])[F:13]

Komponenten

5

Edukt 3

HCID 11430Potassium CarbonateHCID 161915Tosylmethyl isocyanideHCID 27375373-Fluoro-4-(trifluoromethyl)benzaldehyde

Produkt 1

HCID 86699311Oxazole, 5-[3-fluoro-4-(trifluoromethyl)phenyl]-

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

A solution of 3-fluoro-4-(trifluoromethyl)benzaldehyde (1.40 g, 7.07 mmol) and p-toluenesulfonylmethyl isocyanide (1.53 g, 7.68 mmol; TosMIC) in MeOH (100 mL) was treated with potassium carbonate (1.97 g, 14.14 mmol) and the suspension heated to reflux for 14 h. After being cooled to room temperature, the solvent was removed under reduced pressure and the crude product triturated with water at 0° C. (2×25 mL). The slightly orange precipitate was collected by filtration and dried under vacuum (4.46 g, 92%). MS: 232.0 (M+H)+.

Aufarbeitung

  1. temperaturethe suspension heated
  2. temperatureto reflux for 14 h
  3. customthe solvent was removed under reduced pressure
  4. customthe crude product triturated with water at 0° C. (2×25 mL)
  5. filtrationThe slightly orange precipitate was collected by filtration
  6. customdried under vacuum (4.46 g, 92%)

Quellen und Nachweise

ORD-Eintrag
ord-6700f5b63f0847f69204989a9b920da9
Quelldatensatz
uspto-grants-2015_11
Patentnummer
US09187429B2

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