N-(2-(4-nitro-1H-pyrazol-1-yl)ethyl)methanesulfonamide → N-(2-(4-amino-1H-pyrazol-1-yl)ethyl)methanesulfonamide

HRID 714904Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 714904
[N+:1]([C:4]1[CH:5]=[N:6][N:7]([CH2:9][CH2:10][NH:11][S:12]([CH3:15])(=[O:14])=[O:13])[CH:8]=1)([O-])=O>C(O)C.[C].[Pd]>[NH2:1][C:4]1[CH:5]=[N:6][N:7]([CH2:9][CH2:10][NH:11][S:12]([CH3:15])(=[O:14])=[O:13])[CH:8]=1

Komponenten

4

Edukt 1

HCID 117840477N-(2-(4-nitro-1H-pyrazol-1-yl)ethyl)methanesulfonamide

Produkt 1

HCID 73439022N-(2-(4-amino-1H-pyrazol-1-yl)ethyl)methanesulfonamideAusbeute 112,1 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 178418390HCID 178418390, VerbindungKatalysatorHCID 702EthanolLösungsmittel

Versuchsvorschrift

To a solution of N-(2-(4-nitro-1H-pyrazol-1-yl)ethyl)methanesulfonamide (880 mg) obtained in Step A of Example 349 in ethanol (30 mL) was added 10% palladium-carbon (200 mg), and the mixture was stirred at room temperature for 3 hr under hydrogen atmosphere (at normal pressures). The palladium carbon was removed by filtration through Celite, and the solvent was evaporated under reduced pressure to give the title compound (860 mg).

Aufarbeitung

  1. customThe palladium carbon was removed by filtration through Celite
  2. customthe solvent was evaporated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-844c77046182491c837eb0f12d8ea02a
Quelldatensatz
uspto-grants-2015_11
Patentnummer
US09187453B2

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