Methanol → Methyl p-aminosalicylate

HRID 71535

Reaktionsgleichung

Reaktionsgleichung von HRID 71535
[NH2:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=[O:7])=[C:4]([OH:11])[CH:3]=1.[CH3:12]O>>[OH:11][C:4]1[CH:3]=[C:2]([CH:10]=[CH:9][C:5]=1[C:6]([O:8][CH3:12])=[O:7])[NH2:1]

Komponenten

3

Edukt 2

HCID 887MethanolHCID 46494-Aminosalicylic Acid

Produkt 1

HCID 77787Methyl p-aminosalicylate

Versuchsvorschrift

A solution of 4-amino-2-hydroxybenzoic acid (1 g, 6.5 mmol) in MeOH (15 mL) and concentrated sulfonic acid (1 mL) was refluxed overnight. The reaction mixture was quenched with NaHCO3 aqueous solution (60 mL) and EtOAc (60 mL). The organic layer was separated, dried, evaporated to give 3-hydroxy-4-methoxycarbonylaniline.

Aufarbeitung

  1. customThe reaction mixture was quenched with NaHCO3 aqueous solution (60 mL) and EtOAc (60 mL)
  2. customThe organic layer was separated
  3. customdried
  4. customevaporated

Quellen und Nachweise

ORD-Eintrag
ord-aba6bdb960ce41dead32062ee1bf5d05
Quelldatensatz
uspto-grants-2014_09
Patentnummer
US08822685B2

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