Sodium ethoxide → Ethyl (6-ethoxy-4-methylpyridazin-3-yl)carbamate
Reaktionsgleichung
Cl[C:2]1[N:7]=[N:6][C:5]([NH:8][C:9](=[O:13])[O:10][CH2:11][CH3:12])=[C:4]([CH3:14])[CH:3]=1.[O-:15][CH2:16][CH3:17].[Na+]>>[CH2:16]([O:15][C:2]1[N:7]=[N:6][C:5]([NH:8][C:9](=[O:13])[O:10][CH2:11][CH3:12])=[C:4]([CH3:14])[CH:3]=1)[CH3:17]Komponenten
3
Reaktionsbedingungen
- Temperatur
- 110 °C
Versuchsvorschrift
A 20 mL microwavable vial was charged with ethyl (6-chloro-4-methylpyridazin-3-yl)carbamate (550 mg, 2.55 mmol) and sodium ethoxide (3.11 mL, 17.85 mmol), then stirred and heated at 110° C. for 12 h. The reaction mixture was then concentrated and partitioned between ammonium chloride and DCM. The layers were separated and the aqueous layers were washed with DCM (2×). The combined organic layers were washed with water, brine, and eluted through a phase separator. The organic layers were concentrated to afford ethyl (6-ethoxy-4-methylpyridazin-3-yl)carbamate (398 mg, 65.8% yield).