Ammonia → HCID 86701048, Verbindung
Reaktionsgleichung
[NH3:1].[F:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[C:9]1[N:13]2[N:14]=[C:15]([S:18][CH:19]([CH2:25][CH3:26])[C:20](OCC)=[O:21])[CH:16]=[CH:17][C:12]2=[N:11][N:10]=1>CO>[F:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[C:9]1[N:13]2[N:14]=[C:15]([S:18][CH:19]([CH2:25][CH3:26])[C:20]([NH2:1])=[O:21])[CH:16]=[CH:17][C:12]2=[N:11][N:10]=1Komponenten
4
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Reaktionsbedingungen
- Temperatur
- 50 °C
Versuchsvorschrift
To 10 ml of dry methanol saturated with ammonia was added 0.5 mmol of ethyl 2-((3-(2-fluorophenyl)-[1,2,4]triazolo[4,3-b]pyridazin-6-yl)thio)butanoate. The pressure tube was stoppered tightly, and the solution was stirred for 16 hours at 50° C. The white precipitate was collected and washed with cold methanol to give 2-((3-(2-fluorophenyl)-[1,2,4]triazolo[4,3-b]pyridazin-6-yl)thio)butanamide.