Methanol → HCID 89051975, Verbindung

HRID 716099Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 716099
C(N[CH:9]1[O:16][C@H:15]([CH2:17][OH:18])[C@@H:13]([OH:14])[C@H:11]([OH:12])[C@@H:10]1[NH:19][CH2:20][C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1)C1C=CC=CC=1.C[OH:28]>>[CH2:20]([NH:19][C@@H:10]([C@H:11]([C@@H:13]([C@@H:15]([CH2:17][OH:18])[OH:28])[OH:14])[OH:12])[CH:9]=[O:16])[C:21]1[CH:22]=[CH:23][CH:24]=[CH:25][CH:26]=1

Komponenten

3

Edukt 2

HCID 887MethanolHCID 70874206HCID 70874206, Verbindung

Produkt 1

HCID 89051975HCID 89051975, Verbindung

Reaktionsbedingungen

Temperatur
40 °C

Versuchsvorschrift

From compound of example 1: to a suspension of N,N′-dibenzyl-1,2-diamino-1,2-dideoxy-D-mannopyranose (10 g) in methanol (30 ml) conc. HCl-solution (4 ml) was gradually added and the mixture was heated to 40° C. for 2-3 hours. The solvent was carefully evaporated, the residue was taken up in methanol and evaporated again 3-4 times. The resulting solid was suspended in ethanol and heated to reflux, the insoluble material was removed by hot filtration, and the filtrate was evaporated to dryness to yield the hydrochloride salt of N-benzyl-2-amino-2-deoxy-D-mannose.

Aufarbeitung

  1. additionwas gradually added
  2. customThe solvent was carefully evaporated
  3. customevaporated again 3-4 times
  4. temperatureheated
  5. temperatureto reflux
  6. customthe insoluble material was removed by hot filtration
  7. customthe filtrate was evaporated to dryness

Quellen und Nachweise

ORD-Eintrag
ord-b6bcac4e9ccd44d08c937c3350bb6f44
Quelldatensatz
uspto-grants-2015_11
Patentnummer
US09187513B2

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