Sodium Hydroxide → 3-Chlorophenylglyoxylic acid

HRID 716732Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 716732
[OH-].[Na+].[Cl:3][C:4]1[CH:5]=[C:6]([C:10](=[O:16])[C:11]([O:13]CC)=[O:12])[CH:7]=[CH:8][CH:9]=1>C1COCC1.CO>[Cl:3][C:4]1[CH:5]=[C:6]([C:10](=[O:16])[C:11]([OH:13])=[O:12])[CH:7]=[CH:8][CH:9]=1

Komponenten

4

Edukt 2

HCID 14798Sodium HydroxideHCID 2758814ethyl 2-(3-chlorophenyl)-2-oxoacetate

Produkt 1

HCID 122529103-Chlorophenylglyoxylic acidAusbeute 115,2 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 21899815MeOH tetrahydrofuranLösungsmittel

Versuchsvorschrift

An aqueous 2 mol/L NaOH solution (24 mL) was added to a solution of ethyl (3-chlorophenyl)(oxo)acetate (2.00 g) in THF/MeOH (1:1) (48 mL) in an ice bath, followed by stirring at room temperature overnight. The solvent was distilled off under reduced pressure, and an aqueous 3 mol/L HCl solution was added thereto in an ice bath. The precipitated solid was collected by filtration to yield the title compound (2.00 g, colorless solid).

Aufarbeitung

  1. distillationThe solvent was distilled off under reduced pressure
  2. additionan aqueous 3 mol/L HCl solution was added
  3. filtrationThe precipitated solid was collected by filtration

Quellen und Nachweise

ORD-Eintrag
ord-ed40ffaa3da34e729845a2fd9b3e881b
Quelldatensatz
uspto-grants-2015_11
Patentnummer
US09193695B2

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