Phenethylamine → Formamide, N-(2-phenylethyl)-

HRID 716953

Reaktionsgleichung

Reaktionsgleichung von HRID 716953
[C:1]1([CH2:7][CH2:8][NH2:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH:10](OCC)=[O:11]>>[CH2:8]([NH:9][CH:10]=[O:11])[CH2:7][C:1]1[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Komponenten

3

Edukt 2

HCID 1001PhenethylamineHCID 8025Ethyl formate

Produkt 1

HCID 140995Formamide, N-(2-phenylethyl)-

Reaktionsbedingungen

Temperatur
50 °C

Versuchsvorschrift

Into a 100-mL 3-necked round-bottom flask purged and maintained with an inert atmosphere of nitrogen, was placed 2-phenylethanamine (1.9 g, 15.70 mmol, 1.00 equiv). This was followed by the addition of ethyl formate (5 g, 67.57 mmol, 4.30 equiv) dropwise with stiffing. The resulting solution was stirred overnight at 50° C. The resulting solution was concentrated under vacuum. The residue was applied onto a silica gel column with dichloromethane/methanol (70:1). This resulted in 2.27 g (97%) of N-phenethylformamide as yellow oil.

Aufarbeitung

  1. customInto a 100-mL 3-necked round-bottom flask purged
  2. temperaturemaintained with an inert atmosphere of nitrogen
  3. concentrationThe resulting solution was concentrated under vacuum
  4. customThis resulted in 2.27 g (97%) of N-phenethylformamide as yellow oil

Quellen und Nachweise

ORD-Eintrag
ord-3297cd83d6744d5c9fce381b2a37e689
Quelldatensatz
uspto-grants-2015_11
Patentnummer
US09193693B2

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