2-[2-({[2-(4-Bromo-phenyl)-2-oxo-ethyl carbamoyl]-methyl}-tert-butoxycarbonyl-amino)-acetylamino]-3-methyl-butyric acid methyl ester → 2-[2-({[2-(4-Bromo-phenyl)-2-oxo-ethylcarbamoyl]-methyl}-tert-butoxycarbonyl-amino)-acetylamino]-3-methyl-butyric acid

HRID 71760

Reaktionsgleichung

Reaktionsgleichung von HRID 71760
C[O:2][C:3](=[O:34])[CH:4]([NH:8][C:9](=[O:33])[CH2:10][N:11]([CH2:19][C:20](=[O:32])[NH:21][CH2:22][C:23]([C:25]1[CH:30]=[CH:29][C:28]([Br:31])=[CH:27][CH:26]=1)=[O:24])[C:12]([O:14][C:15]([CH3:18])([CH3:17])[CH3:16])=[O:13])[CH:5]([CH3:7])[CH3:6].COC(N1CC(=O)N2C(C(OCC)=O)CCC2C1)=O>>[Br:31][C:28]1[CH:27]=[CH:26][C:25]([C:23](=[O:24])[CH2:22][NH:21][C:20]([CH2:19][N:11]([C:12]([O:14][C:15]([CH3:16])([CH3:18])[CH3:17])=[O:13])[CH2:10][C:9]([NH:8][CH:4]([CH:5]([CH3:7])[CH3:6])[C:3]([OH:34])=[O:2])=[O:33])=[O:32])=[CH:30][CH:29]=1

Komponenten

3

Edukt 2

HCID 666202862-[2-({[2-(4-Bromo-phenyl)-2-oxo-ethyl carbamoyl]-methyl}-tert-butoxycarbonyl-amino)-acetylamino]-3-methyl-butyric acid methyl esterHCID 666205494-Oxo-hexahydro-pyrrolo[1,2-a]pyrazine-2,6-dicarboxylic acid 6-ethyl ester 2-methyl ester

Produkt 1

HCID 666200102-[2-({[2-(4-Bromo-phenyl)-2-oxo-ethylcarbamoyl]-methyl}-tert-butoxycarbonyl-amino)-acetylamino]-3-methyl-butyric acid

Versuchsvorschrift

2-[2-({[2-(4-Bromo-phenyl)-2-oxo-ethylcarbamoyl]-methyl}-tert-butoxycarbonyl-amino)-acetylamino]-3-methyl-butyric acid was prepared using method 801 substituting 2-[2-({[2-(4-bromo-phenyl)-2-oxo-ethylcarbamoyl]-methyl}-tert-butoxycarbonyl-amino)-acetylamino]-3-methyl-butyric acid methyl ester for 4-oxo-hexahydro-pyrrolo[1,2-a]pyrazine-2,6-dicarboxylic acid 6-ethyl ester 2-methyl ester. C22H30BrN3O7 calculated 527.1 observed [M+1]+ 528.1; rt=2.39 min.

Aufarbeitung

  1. customrt=2.39 min.

Quellen und Nachweise

ORD-Eintrag
ord-9ffbde8b327a4cbd91a07fff2f05372a
Quelldatensatz
uspto-grants-2014_09
Patentnummer
US08822430B2

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