Ethanol → HCID 15134190, Verbindung

HRID 718690Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 718690
[CH3:1][C:2]1[CH:11]=[CH:10][C:9]2[C:8]([C:12]([OH:14])=[O:13])=[CH:7][CH:6]=[CH:5][C:4]=2[N:3]=1.OS(O)(=O)=O.[CH3:20][CH2:21]O>C(Cl)Cl>[CH3:1][C:2]1[CH:11]=[CH:10][C:9]2[C:8]([C:12]([O:14][CH2:20][CH3:21])=[O:13])=[CH:7][CH:6]=[CH:5][C:4]=2[N:3]=1

Komponenten

5

Edukt 3

HCID 702EthanolHCID 1118Sulfuric AcidHCID 3199762-Methyl-5-quinolinecarboxylic acid

Produkt 1

HCID 15134190HCID 15134190, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

To a slurry of compound 73a (3.1 g, 16 mmol) in EtOH (50 mL) was added concentrated H2SO4 (1.0 mL) and the resultant slurry was refluxed overnight. The homogeneous solution was cooled, diluted with DCM (300 mL), washed with 1N NaOH (1×100 mL), dried (Na2SO4), and concentrated in vacuo to give compound 73b as an off-white solid. Mass spectrum (LCMS, ESI pos.) Calcd. For C13H13NO2: 216.2 (M+H). found 216.2.

Aufarbeitung

  1. temperaturethe resultant slurry was refluxed overnight
  2. temperatureThe homogeneous solution was cooled
  3. washwashed with 1N NaOH (1×100 mL)
  4. dry with materialdried (Na2SO4)
  5. concentrationconcentrated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-fddecac2ec004fb285028b74eb0ac7d7
Quelldatensatz
uspto-grants-2015_11
Patentnummer
US09193736B2

Notizen zur Reaktion

Wird geladen…