Hydrochloric Acid → HCID 21896882, Verbindung

HRID 719122Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 719122
[ClH:1].[CH2:2]([O:4][C:5]1[CH:12]=[C:11]([O:13][CH3:14])[CH:10]=[CH:9][C:6]=1[C:7]#[N:8])[CH3:3].[CH2:15]([OH:17])[CH3:16]>>[ClH:1].[CH2:2]([O:4][C:5]1[CH:12]=[C:11]([O:13][CH3:14])[CH:10]=[CH:9][C:6]=1[C:7](=[NH:8])[O:17][CH2:15][CH3:16])[CH3:3]

Komponenten

4

Edukt 3

HCID 313Hydrochloric Acid2×HCID 702EthanolHCID 218969052-Ethoxy-4-methoxybenzonitrile

Produkt 1

HCID 21896882HCID 21896882, VerbindungAusbeute 79 %

Reaktionsbedingungen

Temperatur
-10 °C

Versuchsvorschrift

Hydrogen chloride gas was passed through a solution of 2-ethoxy-4-methoxy-benzonitrile (6.3 g, 35.55 mmol) in anhydrous ethanol (70 mL) cooled to −10° C. After 30 min, hydrogen chloride gas was stopped and the reaction mixture was stirred at room temperature in a closed reaction vessel for 4 d. The reaction vessel was cooled to 0° C. before the stopper was removed. Argon gas was passed through the solution to remove excess hydrogen chloride gas. The solvent was evaporated and the residue was triturated in diethyl ether (100 mL) to afford ethyl 2-ethoxy-4-methoxy-benzimidate hydrochloride (7.3 g, 79%). It was used without further purification.

Aufarbeitung

  1. temperatureThe reaction vessel was cooled to 0° C. before the stopper
  2. customwas removed
  3. customto remove excess hydrogen chloride gas
  4. customThe solvent was evaporated
  5. customthe residue was triturated in diethyl ether (100 mL)

Quellen und Nachweise

ORD-Eintrag
ord-1cbf5cb58a3f420389ba7b092e4888e9
Quelldatensatz
uspto-grants-2006_11
Patentnummer
US07132421B2

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