Isopropanol → 6-isopropoxy-N-(3-Chloro-4-methoxyphenyl)-N'-cycloheptyl-[1,3,5]triazine-2,4-diamine

HRID 719445Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 719445
Cl[C:2]1[N:7]=[C:6]([NH:8][C:9]2[CH:14]=[CH:13][C:12]([O:15][CH3:16])=[C:11]([Cl:17])[CH:10]=2)[N:5]=[C:4]([NH:18][CH:19]2[CH2:25][CH2:24][CH2:23][CH2:22][CH2:21][CH2:20]2)[N:3]=1.C([O-])([O-])=O.[K+].[K+].[CH:32]([OH:35])([CH3:34])[CH3:33]>>[CH:32]([O:35][C:2]1[N:7]=[C:6]([NH:8][C:9]2[CH:14]=[CH:13][C:12]([O:15][CH3:16])=[C:11]([Cl:17])[CH:10]=2)[N:5]=[C:4]([NH:18][CH:19]2[CH2:25][CH2:24][CH2:23][CH2:22][CH2:21][CH2:20]2)[N:3]=1)([CH3:34])[CH3:33]

Komponenten

4

Edukt 3

HCID 3776IsopropanolHCID 11430Potassium CarbonateHCID 218970216-chloro-N-(3-chloro-4-methoxyphenyl)-N'-cycloheptyl-[1,3,5]triazine-2,4-diamine

Produkt 1

HCID 114951456-isopropoxy-N-(3-Chloro-4-methoxyphenyl)-N'-cycloheptyl-[1,3,5]triazine-2,4-diamine

Versuchsvorschrift

To a portion of 6-chloro-N-(3-chloro-4-methoxyphenyl)-N′-cycloheptyl-[1,3,5]triazine-2,4-diamine (5 g) in isopropanol was added K2CO3 (3.2 g) and refluxed for about 10–12 h. TLC was monitored. After the completion of the reaction, the reaction mass was filtered through vacuum and the filtrate was evaporated to yield the title compound. (Wt. 3.7 g Y: 70%).

Aufarbeitung

  1. temperaturerefluxed for about 10–12 h
  2. customAfter the completion of the reaction
  3. filtrationthe reaction mass was filtered through vacuum
  4. customthe filtrate was evaporated

Quellen und Nachweise

ORD-Eintrag
ord-6b423a9b8ee847bfb5257d32b0ac1b61
Quelldatensatz
uspto-grants-2006_11
Patentnummer
US07132423B2

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